Dynamics of Serum Pregenome RNA in Chronic Hepatitis B Patients Receiving 96-Month Nucleos(t)ide Analog Therapy.

Front Med (Lausanne) · 2022 · PMC8918695 · PMID 35295596

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a decreasing trendno p-value reported

We monitored the dynamic change of serum pgRNA during the long-term NAs therapy, and found that serum pgRNA in most patients, generally speaking, showed a decreasing trend from baseline to 96 months after treatment, which was contrast with the earlier results that serum pgRNA increased both in CHB patients ( 10 ) and in HBV transgenic mice with NAs therapy ( 9 ).

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