extremely significantP <0.001
Statistical significance of P -values (GraphPad format) is abbreviated on plots as follows: not significant (ns) where P ≥0.05, significant (*) where 0.01≤ P <0.05, very significant (**) where 0.001≤ P <0.01, extremely significant (*** and ****) where 0.0001≤ P <0.001 and P <0.0001, respectively.