Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors.

In the present study, we demonstrate that arginine deprivation using ADI-PEG20 favorably alters the immune microenvironment of ASS1-positive GBM tumors and in combination with ionizing radiation (IR) leads to complete tumor elimination with a highly significant increase in survival.

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Moreover, although Ym1 expression was not significantly altered in either condition, its downregulation was trending toward significance with combined treatment ( Figure 6D ).

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