borderline significancep=0.051
91 - 95 A meta-analysis of seven cohort studies in 2017 showed that metformin was associated with a 24% lower GC risk, 87 but a recent meta-analysis of 14 cohort studies reported a similar magnitude of effect (21% lower risk) albeit with borderline significance (95% CI, 0.63 to 1.00; p=0.051).