Trans-acting genetic variants causing multilocus imprinting disturbance (MLID): common mechanisms and consequences.

Whereas the majority of MLID carriers show specific phenotypes associated with LOM of the disease-specific DMRs (primary epimutations, Table 1 ), the epigenetic pattern of other affected DMRs is more or less arbitrary, with a slight trend as described before: PLAGL1 , GRB10 and GNAS LOM rather appear to predispose to a BWS phenotype, though they can be altered in other imprinting disorders as well.

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