The interacting physiology of COVID-19 and the renin-angiotensin-aldosterone system: Key agents for treatment.

The RAS, the lung, and ACE2 The role of the RAS in pulmonary vascular endothelium is extremely significant because the entire capillary network of the lung contains ACE whereas only about 20% of the capillary network in other organs express ACE. 76 This explains the well‐known fact that the lung is the major site for the conversion of Ang I to Ang II.

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These other Ang II producing pathways may be significant for intracrine production of Ang II.

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