As a likely compensatory response, 1 h after chemogenetic activation, microglial process coverage increased around endothelial cells (P = 0.001) and smooth muscle cells (P = 0.026), whereas a nonsignificant trend was observed in process coverage of pericytes ( Fig. 4 h ).
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Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions.
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