Randomised controlled trials of mood stabilisers for people with autism spectrum disorder: systematic review and meta-analysis.

24 In the second placebo-controlled trial by the same group on 27 children, a marginally statistically significant improvement was seen with divalproex sodium compared with placebo in reducing irritability when measured by the ABC scale, but no such significant reduction in irritability (we are, however, not aware of any irritability measure in OAS-M) was found when measured by OAS-M. 25 This finding did not change when IQ difference was controlled for.

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26 The only placebo-controlled double-blind RCT included in our review on lamotrigine 23 showed a marginally significant difference in improvement in adaptive social behaviours but did not show any inter-group difference for any of the other outcomes.

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