In Gabrb3 ECKO mice, responses to acoustic startle showed an increasing trend at higher startle intensities than in Gabrb3 fl/fl mice, but the response did not significantly differ between the two groups at startle intensities from 20 to 120 dB (Fig. 3 d).
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Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction.
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The percentage of inhibition showed a decreasing trend in Gabrb3 ECKO mice when compared to controls and was significantly decreased at 85 dB intensity (Fig. 3 e).