Tryptophan depletion results in tryptophan-to-phenylalanine substitutants.

Nature · 2022 · PMC8942854 · PMID 35264796

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highly significantP < 2.2 × 10 −16actually significant

The enrichment for tryptophan-depletion-induced W>F peptides (44 versus 4) is highly significant, considering the globally reduced protein expression ( P < 2.2 × 10 −16 ; Fig. 2b, d ).

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