TLR7 ligation augments hematopoiesis in Rps14 (uS11) deficiency via paradoxical suppression of inflammatory signaling.

Blood Adv · 2021 · PMC8945628 · PMID 34432872

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highly significantno p-value reported

Systems level analysis of genes confirmed highly significant knockdown of Rps14 at the RNA level in HSPCs in heterozygotes across all conditions ( Figure 5C ). 36 Pathway analysis of genes differentially regulated in Rps14 +/− compared with Rps14 +/+ embryos demonstrated enrichment of pathways involving ribosome biogenesis, translation, and p53 and TNFα/NF-κ

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