extremely significantp < 0.0001
* indicates p -value 0.01 to 0.05 (significant), ** indicates p -value 0.001 to 0.01 (very significant), *** indicates p -value 0.0001 to 0.001 (extremely significant), **** indicates p -value p < 0.0001 (extremely significant), ns indicates p ≥ 0.05 not significant. 3.