Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?

Treatment of hTert keratinocytes with the 4B3 antibody resulted in a highly significant depletion of FcRn, whereas hAK23 and mAK23, as well as the control hIgGs only induced a minor reduction that was not significant ( Figure 3 d).

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