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Inducible Nitric Oxide Synthase (iNOS): Why a Different Production in COVID-19 Patients of the Two Waves?

Viruses · 2022 · PMC8948744 · PMID 35336941

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an increasing trendno p-value reported
Furthermore, an increasing trend of serum iNOS, related to the WHO stage, was observed among untreated patients.

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a decreasing trendno p-value reported
In the first wave, serum IL-6, IL-10, and iNOS levels increased significantly along the WHO stage, while, in the second wave, IL-6 levels were variable, IL-10 showed a decreasing trend and iNOS did not change.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.