Analysis of ALP early mineralization marker transcript levels revealed a significant 1.3-fold upregulation upon cyclic strain in collagen-surface grown PDL cells, while YAP1 knockdown resulted in a drastic and highly significant 6-fold reduction of ALP transcript levels ( Figure 3 A, ALP graph).
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The Hippo Pathway Effectors YAP/TAZ Are Essential for Mineralized Tissue Homeostasis in the Alveolar Bone/Periodontal Complex.
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