In the Framingham Heart Study, using stored serum samples, subjects with serum 25OHD concentrations below 15 ng/mL had a 60% higher risk of a cardiovascular event over a 7-year time period, and this remained highly significant even after adjustment for other risk factors [ 43 ].
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Calcifediol (25OH Vitamin D<sub>3</sub>) Deficiency: A Risk Factor from Early to Old Age.
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The sentences
The ViDA trial also did not find an effect on cancer mortality whereas the larger VITAL trial showed a marginally significant lower cancer mortality in subjects receiving vitamin D (2000 IU/d), especially when deaths during the first 2 years of follow up were excluded.
When several trials were combined, a modestly significant lower cancer mortality was found in the subjects receiving vitamin D supplements [ 65 ].