Barely Significant
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Shikonin Derivatives Inhibit Inflammation Processes and Modulate MAPK Signaling in Human Healthy and Osteoarthritis Chondrocytes.

Int J Mol Sci · 2022 · PMC8955849 · PMID 35328817

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highly significantno p-value reported
Acetylshikonin and shikonin showed a highly significant reduction in these markers in pCH-OA cells, normally being upregulated in the clinical pattern of OA.

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