highly significantp = 0.0022
This decrease was highly significant in the naive group (N-peptide, p = 0.0022, R-, p = <0.0003, and C-, p = 0.0367) whereas it was non-significant in the semi-immune group (N-peptide, p = 0.902, R- p = 0.263, and C-, p = 0.371) (Fig. 4 ).