Overexpression of the Hsa21 Transcription Factor RUNX1 Modulates the Extracellular Matrix in Trisomy 21 Cells.

Several lines of evidence support the role of RUNX1 as a regulator of ECM genes: 1) Runx1 is the only gene causing the upregulation of ECM genes from overexpression experiments of 32 Hsa21 transcription factors and regulators in mouse embryo cells ( De Cegli et al., 2010 ); 2) GSEA analysis of four experiments ( Table 2 ) in which RUNX1 gene expression was modulated, demonstrated that the ECM Cell Component GO category is always affected by RUNX1 modulation in different organisms and conditions, despite few genes being consistently dysregulated across all four sets; 3) there is a highly significant affinity of the RUNX1 Position Frequency matrix to the ECM genes upregulated in DS fetal hearts.

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