Effects of Gut Microbiota on Host Adaptive Immunity Under Immune Homeostasis and Tumor Pathology State.

Although the current findings about the antigen mimic of commensal bacteria are not abundant, due to the huge number of commensal bacteria genomes and the high cross-reactivity of TCR, antigen mimic may be significant in strengthening antitumor adaptive immunity. 3.2 Gut Microbiota Promotes the Initiation of Antitumor Adaptive Immunity to Assist ICB Therapies In order to trigger an effective antitumor response, tumor antigens must be taken up by DCs and presented through MHC-II and/or MHC-I to activate CD4+ T cells and CD8+ T cells, respectively.

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