An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.

Nat Cancer · 2022 · PMC8960412 · PMID 35256819

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In tumors we observed an increasing trend for Ki67 + , CD226 + and KCNA3 + in CD8 + T cells, and a decreasing trend for T regs , SLAMF6 – TIM3 + and TOX + terminally exhausted CD8 + T (T TE ) cells (Fig. 5g,h ).

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