Integrative analyses of genes related to femoral head osteonecrosis: an umbrella review of systematic reviews and meta-analyses of observational studies.

In this study, the allele and recessive models of rs1799889 showed a highly significant association with steroid-induced FHON.

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Rs1799983 and rs2070744 also showed barely significant results and excessive heterogeneity with I 2 values of 80.20% and 90%, respectively.

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The PAI-1 rs1799889 genetic variant showed an exceedingly significant p value of under 0.0005 in the homozygote model and dominant model, with a moderate evidence class in the study by Gong et al.

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This result of rs361525 showed extremely significant and strong evidence with a score of AAB in the Venice criteria.

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