Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (<i>HTR2A</i>) in the Human Placenta.

Biomedicines · 2022 · PMC8962258 · PMID 35203678

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hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

borderline significantp = 0.054so close (0.05 < p ≤ 0.1)

In the rs6306 CC subgroup ( Figure 3 b), we found a borderline significant ( p = 0.054) interaction between neonatal sex and pBWS, with L3/L4 methylation statistically significantly decreased by maternal overweight/obesity only in female placentas.

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marginally significantno p-value reported

In a previous study in an undivided sample of female and male newborns, a marginally significant increase in L3/L4 methylation was observed in placentas exposed to maternal tobacco use [ 50 ].

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