In Silico and In Vitro Screening of Natural Compounds as Broad-Spectrum β-Lactamase Inhibitors against Acinetobacter baumannii New Delhi Metallo-β-lactamase-1 (NDM-1).

Biomed Res Int · 2022 · PMC8966755 · PMID 35372567

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highly significantno p-value reported

Withaferin A (128 mg/L) exhibited highly significant synergistic/potentiating effect with imipenem tested against carbapenem-resistant A. baumannii clinical strain (FIC index of 0.3125) followed by mangiferin, (128 mg/L) with an FIC index of 0.625.

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<i>In Silico</i> and <i>In Vitro</i> Screening of Natural Compounds as Broad-Spectrum <i>β</i>-Lactamase Inhibitors against <i>Acinetobacter baumannii</i> New Delhi Metallo-<i>β</i>-lactamase-1 (NDM-1).

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