NU-9 improves health of hSOD1^G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone.

Both riluzole (500 nM), and edaravone (1 μM) also slightly increased the average length of diseased UMNs, albeit they failed to reach significance (riluzole (500 nM): 274.83 ± 9.83 μm, n = 116 neurons from n = 3 mice; adjusted p -value = 0.2749, Fig. 3 g,j; edaravone (1 μM): 289.58 ± 22.71 μm; n = 120 neurons from n = 3 mice; adjusted p -value = 0.1196, Fig. 3 h,j).

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