MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats.

Function enrichment analysis showed that the GO terms were mainly related to angiogenesis, regulation of the apoptotic process, regulation of MAPK cascade, positive regulation of protein kinase activity, fatty acid metabolic process, regulation of phagocytosis, positive regulation of protein kinase B signaling, regulation of ERK1/2 (extracellular regulated protein kinases) cascade, gliogenesis, and interleukin-1 beta production ( Figure 5B ), with highly significant enrichment of pathways for angiogenesis, endothelial cell proliferation and ErbB, similar to findings after aerobic exercise ( Figure 5D ).

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