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Impact of a Multimodal Analgesia Protocol in an Intensive Care Unit: A Pre-post Cohort Study.

Cureus · 2022 · PMC8971103 · PMID 35371872

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an increasing trendno p-value reported
There was an increasing trend in the use of adjuvant analgesics and morphine in preemptive and therapeutic analgesia.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.