Hence, counting of atretic follicles was only conducted in those anovulatory OoGpr54 −/− mice, which confirmed the highly significant rise of the percentage of large antral follicles undergoing atresia, without changes in the total number of antral follicles per ovary ( Fig. 2B ).
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Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure.
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