The Gαs-protein-mediated pathway may be steadily stimulated by prostanoid EP2 receptors, but not by EP4 receptors.

As PGE 2 is well known to play a role in inflammation, the novel role‐sharing mechanisms regulated by EP2 and EP4 receptors may be significant for terminating PGE 2 ‐evoked inflammation and/or maintaining the homeostasis, e.g., of colorectal tissues/cell functions.

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