Accurate interpretation of thyroid dysfunction during pregnancy: should we continue to use published guidelines instead of population-based gestation-specific reference intervals for the thyroid-stimulating hormone (TSH)?

Although we demonstrated an increasing trend in the median of TSH from the first trimester to the third trimester, which is compatible with the data of these two studies from Turkey, no significant change in TSH median values was observed between the second and third trimester ( P = 0.058).

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