The dihydrofolate reductase 19-bp deletion modifies the beneficial effect of B-vitamin therapy in mild cognitive impairment: pooled study of two randomized placebo-controlled trials.

In the HK trial, a negative interaction between aspirin and FA-containing B vitamins in cognitive functioning was found, and the VITACOG trial also found a borderline significant negative interaction effect of aspirin on the effects of FA-containing B vitamins in brain atrophy ( 7 , 12 ).

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There were significant interaction effects of DHFR genotype (‘ del/del ’, ‘ del/ins ’ and ‘ ins/ins ’) for changes in Clinical Dementia Rating scale-global score (ΔCDR-global) and CDR-sum of boxes score (ΔCDR-SOB) and for Δexecutive function Z -scores with borderline significance ( P interaction = 0.017, 0.014 and 0.052, respectively; data not shown).

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