Static and treatment-responsive brain biomarkers of depression relapse vulnerability following prophylactic psychotherapy: Evidence from a randomized control trial.

Post-hoc analysis confirmed this relationship was significant for non-relapsers, R 2 = 0.075, p = .002, but failed to reach significance for relapsers, R 2 = 0.046, p = .198. 3.3 Static (Treatment-Invariant) relapse biomarkers To identify treatment-invariant (static) neural biomarkers of relapse (Aim 1), dysphoric neural reactivity across both timepoints (baseline and post-intervention) was regressed onto relapse status over the 24-month follow-up period.

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