Barely Significant
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The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990-2019: Findings from the Global Burden of Disease Study 2019.

Lancet Reg Health Eur · 2022 · PMC8980870 · PMID 35392452

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a decreasing trendno p-value reported
Although Central and Eastern Europe had the highest alcohol and drug attributable burdens 30 a decreasing trend of alcohol use disorders in these countries was observed during the study period.

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