Environmental factors in offspring of parents with mood disorders and their role in parent-child transmission: findings from a 14-year prospective high-risk study.

Table 5 reveals that the HR for the strong association between early-onset parental BPD and the emergence of (hypo)manic episodes in offspring (Model 1) only diminished of 15.0% from 8.0 to 6.8 after the introduction of the effect of parental separation and remained highly significant, whereas parental separation was not significantly associated with the emergence of (hypo)manic episodes in offspring (Model 2).

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