Ganoderma tsugae prevents cognitive impairment and attenuates oxidative damage in d-galactose-induced aging in the rat brain.

PLoS One · 2022 · PMC8989198 · PMID 35390035

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a decreasing trendno p-value reported

In aging brains, BDNF expression generally demonstrates a decreasing trend, which is indicative of a reduction in neurogenesis and neuronal activity [ 47 , 48 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.