Role of preexisting inhibitory control deficits vs. drug use history in mediating insensitivity to aversive consequences in a rat model of polysubstance use.

4b ), a relationship supported by the highly significant inverse correlation between avoidance accuracy and number of escape foot shocks reported in the cocaine/yoked-saline matrix ( r = − 0.966, p < 2.8 × E − 017; Table S6 , Supplementary Results) and the heroin + cocaine/yoked-saline matrix ( r = − 0.966, p < 4.4 × E − 016; Table S7 , Supplementary Results).

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