In contrast, the probabilities of obtaining an NEM label at any of the cysteines in the C49Y mutant and R75P mutant were not statistically different from those of WT NOTCH3, although a positive trend was observed at position 9 in the C49Y mutant (Fig. 2d–e ).
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Oligomerization, trans-reduction, and instability of mutant NOTCH3 in inherited vascular dementia.
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