The centrum semiovale showed the greatest statistical power to detect brain regions with highly significant t ‐values, as well as the highest ACR (ACR CS = 1.7%) compared to the cerebellum GM and pons.
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Tracer-specific reference tissues selection improves detection of <sup>18</sup> F-FDG, <sup>18</sup> F-florbetapir, and <sup>18</sup> F-flortaucipir PET SUVR changes in Alzheimer's disease.
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