Characterization of Aberrations in DNA Damage Repair Pathways in Gastrointestinal Stromal Tumors: The Clinicopathologic Relevance of γH2AX and 53BP1 in Correlation with Heterozygous Deletions of CHEK2, BRCA2, and RB1.

Cancers (Basel) · 2022 · PMC8997382 · PMID 35406559

Europe PMC DOI

hedged sentences

0.0660

closest p · 1.3× alpha

0.0660

boldest claim

The sentences

a marginal trendp = 0.066so close (0.05 < p ≤ 0.1)

Although the co-deletion of RB1 and BRCA2 was only seen in two cases, it showed a marginal trend toward association among all primary GISTs ( p = 0.066), partly reflective of their chromosomal proximity.

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highly significantno p-value reported

Similarly, variations in the IF expression levels of γ-H2AX and 53BP1 were also highly significant when compared among normal tissue and two combined groups comprising GISTs at different risk levels.

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trend toward significanceno p-value reported

Despite the marginal trend toward significance, the frequency of RB1/BRCA2 co-deletion was even lower (~5%, 2/41) in GISTs analyzed by MLPA, indicating independent alterations of either gene in a subset of primary GISTs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Characterization of Aberrations in DNA Damage Repair Pathways in Gastrointestinal Stromal Tumors: The Clinicopathologic Relevance of γH2AX and 53BP1 in Correlation with Heterozygous Deletions of <i>CHEK2</i>, <i>BRCA2</i>, and <i>RB1</i>.

The sentences