The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells.

Cells · 2022 · PMC8997856 · PMID 35406744

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borderline significantno p-value reported

Members of SIN3A Complex Are Present at the RARβ Promoter ChIP assays conducted on MDA-MB-231 cells showed the presence of Sin3A ( p = 0.051), which was borderline significant, and MAD1 on the E-box of the RARβ promoter and RARα on the RARE region ( Figure 3 B,C).

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highly significantno p-value reported

The AM80/MS-905 combination showed 100% disease-free survival and inhibition of lung metastasis, which is highly significant from a clinical perspective.

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