After 10 months of therapy with ropinirole, PD patients showed a significant increase in NAA levels from the motor cortex and a highly significant clinical improvement, as shown by the UPDRS motor sub-score.
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Effect of MAO-B Inhibitors on Neurometabolic Profile of Patients Affected by Parkinson Disease: A Proton Magnetic Resonance Spectroscopy Study.
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The sentences
PD patients, compared to HC, showed significantly lower concentrations of NAA in the motor cortex, while the Cho levels showed a decreasing trend.
The Cho concentrations showed a trend towards significance for decrease.