Gut Microbiota: The Potential Key Target of TCM's Therapeutic Effect of Treating Different Diseases Using the Same Method-UC and T2DM as Examples.

Front Cell Infect Microbiol · 2022 · PMC9005880 · PMID 35433500

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The aromatic hydrocarbon receptor (AhR) ligand, the metabolite produced by intestinal Trp-decomposing microorganisms, showed a decreasing trend in the intestines of patients with IBD ( Lamas et al., 2016 ), and recent studies have confirmed that, as a key immunomodulator, AhR ligands potentially induce a variety of cellular and epigenetic mechanisms to attenuate inflammation ( Cannon et al., 2021 ).

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