A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation.

The negative association between the changes at ZGA and upon Snrpb/d2 overexpression is highly significant ( P = 1.1 × 10 −30 , binomial test), suggesting that higher Snrpb/d2 levels before ZGA maintain alternative exon patterns in a more pre-ZGA state, a trend that was also observed for all exons together (fig.

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