Identification of Common and Distinct Pathways in Inflammatory Bowel Disease and Colorectal Cancer: A Hypothesis Based on Weighted Gene Co-Expression Network Analysis.

Front Genet · 2022 · PMC9008839 · PMID 35432477

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highly significantno p-value reported

Most notably, IBD and CRC share significantly increased expression of five genes ( MMP10 , LCN2 , REG1A , REG3A, and DUOX2 ), enriched inflammatory and neutrophil activation pathways and, most notably, highly significant enrichment of IL-4 and IL-13 signaling.

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