Naturally acquired antibodies against 7 Streptococcus pneumoniae serotypes in Indigenous and non-Indigenous adults.

In addition, antibiotic-resistant serotype 19A emerged as replacement disease following the introduction of the first-generation pneumococcal conjugate vaccine (PCV7) in early 2000s, and became highly significant in the epidemiology of pneumococcal infections until immunization with PCV13 greatly reduced its prevalence [ 32 ].

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