Barely Significant
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Patterns of Peripheral Blood B-Cell Subtypes Are Associated With Treatment Response in Patients Treated With Immune Checkpoint Inhibitors: A Prospective Longitudinal Pan-Cancer Study.

Front Immunol · 2022 · PMC9010871 · PMID 35432362

Europe PMCDOI
1
hedged sentence
0.0730
closest p · 1.5× alpha
0.0730
boldest claim

The sentences

close to significancep =0.073so close (0.05 < p ≤ 0.1)
Considering ORR, although close to significance, a relative change in the frequency of CD21 - B-cells was not associated with ORR in the univariable analysis (OR=0.09, 95%CI=0.01-1.25, p =0.073), but reached statistical significance in the multivariable logistic regression model (OR=0.21, 95%CI=0.00-0.71.9, p =0.032). 4 Discussion There is evidence that B-cells and TLS in the tumor microenvironment might be linked to ICI treatment response ( 14 ).

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