Impact of PNPLA3 p.I148M and Hepatic Steatosis on Long-Term Outcomes for Hepatocellular Carcinoma and HBsAg Seroclearance in Chronic Hepatitis B.

Furthermore, it was significantly associated with lower risks for elevated AST and liver cirrhosis ( Table 5 ). Discussion In this study, we found that a diagnosis of hepatic steatosis and its related factors including excess BMI and the PNPLA3-148M allele were associated with higher HBsAg seroclearance rate, and the analysis of their combined effect, summarized as a prognostic score, showed a highly significant increasing trend in the lifetime probability of HBsAg seroclearance with increase in the score.

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