α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor and RNA processing gene dysregulation are early determinants of selective motor neuron vulnerability in a mouse model of amyotrophic lateral sclerosis.

Gene ontology analysis for biological and molecular processes using a less stringent significance threshold (not corrected for multiple testing) was conducted to capture a broader set of dysregulated genes and pathways ( P < 0.01, Supplementary Table 3 ) and showed highly significant enrichment of RNA processing pathways ( Fig. 2C–D ).

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