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Impact of Three Safety Interventions Targeting Off-Label Use of Immediate-Release Fentanyl on Prescription Trends: Interrupted Time Series Analysis.

Front Pharmacol · 2022 · PMC9016332 · PMID 35450053

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an increasing trendno p-value reported
Introduction Although the patterns of use of opioids in Europe are not comparable to the devastating misuse and overuse phenomenon that occurred in the United States in the 2010s, many European countries report an increasing trend in the use of opioids, and some of them are amongst the largest consumers of strong opioids worldwide ( Häuser et al., 2021 ).

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