Barely Significant
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Estradiol and HDL Function in Women - A Partnership for Life.

J Clin Endocrinol Metab · 2022 · PMC9016454 · PMID 34788853

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may be significantno p-value reported
The route by which E2 is administered may be significant in maximizing CVD risk reduction, as transdermal E2 prescribed during perimenopause had no effect on HDL-C but did reduce HDL-CEC compared with placebo ( 8 ).

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